Tuesday, January 30, 2007

Clarification for table 1 of "Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights"

I have been reading your paper titled "Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights" with great interest. Specifically, there is one section that I am confused about that I would like to ask for clarification of: page 1939, column three, paragraph 1, description of table 1. In comparing hubs with simultaneously possible interaction partners to those with mutually exclusive interaction partners, table 1 seems to indicate that the fraction of protein partners with same biological process, molecular function, cellular component and coexpression correlation is higher in hubs with mutually exclusive interactions with partners, however, the text seems to indicate the reverse. I feel that I must be misinterpreting something, so any clarification would be greatly appreciated.

Yes, you're right, unfortunately the column headings of table 1 got switched at a late stage of editing. Since we've been getting a fair share of email about this, there is a note regarding this on the paper website http://sin.gersteinlab.org

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